Official Symbol	LCK
Official Full Name	lymphocyte-specific protein tyrosine kinase
Groups	Non-Receptor Tyrosine Kinases(TK Group)
Superfamily	Protein kinase superfamily
Family	Tyr protein kinase family
Subfamily	SRC subfamily
Other Aliases & Other Designations	lymphocyte-specific protein tyrosine kinase; LCK; RP4-675E8.4; LSK; YT16; p56lck; pp58lck; OTTHUMP00000008640; OTTHUMP00000008740; OTTHUMP00000228508; T-lymphocyte specific protein tyrosine kinase p56lck; leukocyte C-terminal Src kinase; lymphocyte cell-specific protein-tyrosine kinase; p56(LSTRA) protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; t cell-specific protein-tyrosine kinase; tyrosine-protein kinase Lck
EntrezGene ID	3932
HGNC ID	6524
UniProt ID	P06239
Ensembl ID	ENSG00000182866
Refseq Protein ID (Alternative Transcripts)	NP_001036236.1 | NP_005347.3
Protein Sequence	P06239 FASTA Sequence
Chromosome	GeneLoc gene densities for chromosome 1
Strand	Plus strand
Gene Start	32716840 bp from pter
Gene End	32751766 bp from pter
Gene Size	34926 Bases
EntrezGene Cytogenetic Band	1p34.3
Ensembl Cytogenetic Band	1p35.1
HGNC Cytogenetic Band	1p34.3
UniProt Domains & Sequence Similarities	The SH2 domain mediates interaction with SQSTM1. Interaction is regulated by Ser-59 phosphorylation Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily Contains 1 protein kinase domain Contains 1 SH2 domain Contains 1 SH3 domain
InterPro Domains & Families	IPR017441 Protein_kinase_ATP_BS IPR011009 Kinase-like_dom IPR001452 SH3_domain IPR000719 Prot_kinase_cat_dom IPR001245 Ser-Thr/Tyr_kinase IPR000980 SH2 IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
UniProt Function	Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates RUNX3
Gene Ontology GO	Molecular Function Evidence PubMed IDs ATP binding IEA ATPase binding IPI 15671290 CD4 receptor binding IPI 7486703 CD8 receptor binding IPI 2470098 SH2 domain binding ISS antigen binding IEA glycoprotein binding IPI 7513706 kinase activity TAS non-membrane spanning protein tyrosine kinase activity IEA nucleotide binding IEA phosphatidylinositol 3-kinase binding IPI 7504174 protein C-terminus binding IPI 16245368 protein binding IPI 16293614 protein complex binding IEA protein kinase activity protein kinase binding IPI 8618896 protein serine/threonine kinase activity protein serine/threonine phosphatase activity ISS protein tyrosine kinase activity TAS transferase activity transferase activity, transferring phosphorus-containing groups Biological Process Evidence PubMed IDs B cell receptor signaling pathway IEA T cell costimulation TAS T cell differentiation ISS T cell receptor signaling pathway TAS activation of caspase activity ISS aging IEA apoptosis blood coagulation TAS cell surface receptor linked signaling pathway IEA cellular zinc ion homeostasis ISS hemopoiesis NAS 12884910 induction of apoptosis ISS interspecies interaction between organisms IEA leukocyte migration TAS peptidyl-tyrosine phosphorylation IEA phosphorylation TAS platelet activation TAS positive regulation of T cell activation ISS positive regulation of T cell receptor signaling pathway NAS 12614355 positive regulation of gamma-delta T cell differentiation IEA positive regulation of tyrosine phosphorylation of Stat5 protein IEA positive regulation of uterine smooth muscle contraction IEA protein autophosphorylation IEA protein phosphorylation IDA 214242 regulation of T cell receptor signaling pathway regulation of defense response to virus by virus TAS regulation of lymphocyte activation NAS 7852312 release of sequestered calcium ion into cytosol ISS response to drug ISS response to hydrogen peroxide IEA response to mechanical stimulus IEA response to metal ion response to zinc ion IEA viral reproduction TAS Cellular Component Evidence PubMed IDs Golgi apparatus IDA 18029348 blood coagulation TAS cell surface receptor linked signaling pathway IEA cellular zinc ion homeostasis ISS cytoplasm IEA cytosol TAS endocytic vesicle IEA hemopoiesis NAS 12884910 induction of apoptosis ISS interspecies interaction between organisms IEA leukocyte migration TAS membrane raft ISS peptidyl-tyrosine phosphorylation IEA pericentriolar material ISS phosphorylation TAS plasma membrane IEA platelet activation TAS positive regulation of T cell activation ISS positive regulation of T cell receptor signaling pathway NAS 12614355 positive regulation of gamma-delta T cell differentiation IEA positive regulation of tyrosine phosphorylation of Stat5 protein IEA positive regulation of uterine smooth muscle contraction IEA protein autophosphorylation IEA protein phosphorylation IDA 214242 regulation of T cell receptor signaling pathway regulation of defense response to virus by virus TAS regulation of lymphocyte activation NAS 7852312 release of sequestered calcium ion into cytosol ISS response to drug ISS response to hydrogen peroxide IEA response to mechanical stimulus IEA response to metal ion response to zinc ion IEA viral reproduction TAS
EntrezGene Summary	This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. (provided by RefSeq)
OMIM Disorders	OMIM Gene Information : 153390
UniProt Disorders	Involvement in Disease ```````````````````````````````` Note=A chromosomal aberration involving LCK is found in leukemias. Translocation t(1;7)(p34;q34) with TCRB
KEGG Pathways	LCK hsa04380 - Osteoclast differentiation hsa04650 - Natural killer cell mediated cytotoxicity hsa04660 - T cell receptor signaling pathway hsa05340 - Primary immunodeficiency
DrugBank Compounds	Dasatinib {4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic Acid Staurosporine 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine (4-{2-Acetylamino-2-[1-(3-Carbamoyl-4-Cyclohexylmethoxy-Phenyl)-Ethylcarbamoyl}-Ethyl}-2-Phosphono-Phenoxy)-Acetic Acid Phosphoaminophosphonic Acid-Adenylate Ester 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
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© 2012 by Data Mining and Text Mining Laboratory, Department of Bioinformatics, Bharathiar University, Coimbatore 641046, India