Official SymbolLCK
Official Full Namelymphocyte-specific protein tyrosine kinase
GroupsNon-Receptor Tyrosine Kinases(TK Group)
Superfamily Protein kinase superfamily
FamilyTyr protein kinase family
SubfamilySRC subfamily
Other Aliases & Other Designations lymphocyte-specific protein tyrosine kinase; LCK; RP4-675E8.4; LSK; YT16; p56lck; pp58lck; OTTHUMP00000008640; OTTHUMP00000008740; OTTHUMP00000228508; T-lymphocyte specific protein tyrosine kinase p56lck; leukocyte C-terminal Src kinase; lymphocyte cell-specific protein-tyrosine kinase; p56(LSTRA) protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; t cell-specific protein-tyrosine kinase; tyrosine-protein kinase Lck
EntrezGene ID 3932
HGNC ID 6524
UniProt ID P06239
Ensembl ID ENSG00000182866
Refseq Protein ID (Alternative Transcripts) NP_001036236.1 | NP_005347.3
Protein Sequence P06239 FASTA Sequence
ChromosomeGeneLoc gene densities for chromosome 1
StrandPlus strand
Gene Start 32716840 bp from pter
Gene End 32751766 bp from pter
Gene Size 34926 Bases
EntrezGene Cytogenetic Band 1p34.3
Ensembl Cytogenetic Band 1p35.1
HGNC Cytogenetic Band 1p34.3
UniProt Domains & Sequence Similarities The SH2 domain mediates interaction with SQSTM1. Interaction is regulated by Ser-59 phosphorylation

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
Contains 1 protein kinase domain
Contains 1 SH2 domain
Contains 1 SH3 domain
InterPro Domains & Families IPR017441 Protein_kinase_ATP_BS
IPR011009 Kinase-like_dom
IPR001452 SH3_domain
IPR000719 Prot_kinase_cat_dom
IPR001245 Ser-Thr/Tyr_kinase
IPR000980 SH2
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
UniProt Function Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates RUNX3
Gene Ontology GO
Molecular Function Evidence PubMed IDs
ATP bindingIEA
ATPase bindingIPI15671290
CD4 receptor bindingIPI7486703
CD8 receptor bindingIPI2470098
SH2 domain bindingISS
antigen bindingIEA
glycoprotein bindingIPI7513706
kinase activityTAS
non-membrane spanning protein tyrosine kinase activityIEA
nucleotide bindingIEA
phosphatidylinositol 3-kinase bindingIPI7504174
protein C-terminus bindingIPI16245368
protein bindingIPI16293614
protein complex bindingIEA
protein kinase activity
protein kinase bindingIPI8618896
protein serine/threonine kinase activity
protein serine/threonine phosphatase activityISS
protein tyrosine kinase activityTAS
transferase activity
transferase activity, transferring phosphorus-containing groups
Biological Process Evidence PubMed IDs
B cell receptor signaling pathwayIEA
T cell costimulationTAS
T cell differentiationISS
T cell receptor signaling pathwayTAS
activation of caspase activityISS
agingIEA
apoptosis
blood coagulationTAS
cell surface receptor linked signaling pathwayIEA
cellular zinc ion homeostasisISS
hemopoiesisNAS12884910
induction of apoptosisISS
interspecies interaction between organismsIEA
leukocyte migrationTAS
peptidyl-tyrosine phosphorylationIEA
phosphorylationTAS
platelet activationTAS
positive regulation of T cell activationISS
positive regulation of T cell receptor signaling pathwayNAS12614355
positive regulation of gamma-delta T cell differentiationIEA
positive regulation of tyrosine phosphorylation of Stat5 proteinIEA
positive regulation of uterine smooth muscle contractionIEA
protein autophosphorylationIEA
protein phosphorylationIDA214242
regulation of T cell receptor signaling pathway
regulation of defense response to virus by virusTAS
regulation of lymphocyte activationNAS7852312
release of sequestered calcium ion into cytosolISS
response to drugISS
response to hydrogen peroxideIEA
response to mechanical stimulusIEA
response to metal ion
response to zinc ionIEA
viral reproductionTAS
Cellular Component Evidence PubMed IDs
Golgi apparatusIDA18029348
blood coagulationTAS
cell surface receptor linked signaling pathwayIEA
cellular zinc ion homeostasisISS
cytoplasmIEA
cytosolTAS
endocytic vesicleIEA
hemopoiesisNAS12884910
induction of apoptosisISS
interspecies interaction between organismsIEA
leukocyte migrationTAS
membrane raftISS
peptidyl-tyrosine phosphorylationIEA
pericentriolar materialISS
phosphorylationTAS
plasma membraneIEA
platelet activationTAS
positive regulation of T cell activationISS
positive regulation of T cell receptor signaling pathwayNAS12614355
positive regulation of gamma-delta T cell differentiationIEA
positive regulation of tyrosine phosphorylation of Stat5 proteinIEA
positive regulation of uterine smooth muscle contractionIEA
protein autophosphorylationIEA
protein phosphorylationIDA214242
regulation of T cell receptor signaling pathway
regulation of defense response to virus by virusTAS
regulation of lymphocyte activationNAS7852312
release of sequestered calcium ion into cytosolISS
response to drugISS
response to hydrogen peroxideIEA
response to mechanical stimulusIEA
response to metal ion
response to zinc ionIEA
viral reproductionTAS
EntrezGene Summary This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. (provided by RefSeq)
OMIM Disorders OMIM Gene Information : 153390
UniProt Disorders Involvement in Disease
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Note=A chromosomal aberration involving LCK is found in leukemias. Translocation t(1;7)(p34;q34) with TCRB
KEGG Pathways LCK
hsa04380 - Osteoclast differentiation
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04660 - T cell receptor signaling pathway
hsa05340 - Primary immunodeficiency
DrugBank Compounds
  • Dasatinib
  • {4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic Acid
  • Staurosporine
  • 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
  • (4-{2-Acetylamino-2-[1-(3-Carbamoyl-4-Cyclohexylmethoxy-Phenyl)-Ethylcarbamoyl}-Ethyl}-2-Phosphono-Phenoxy)-Acetic Acid
  • Phosphoaminophosphonic Acid-Adenylate Ester
  • 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
  • 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE
  • 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
  • N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
  • N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
  • N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
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